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  • 产品名称：Anti-BMP6 antibody (350-450) [S8MR] (STJ11102098)

  • 产品型号：STJ11102098
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-BMP6 antibody (350-450) [S8MR] (STJ11102098)
详情介绍：
Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-BMP6 (350-450) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Monoclonal
Clone ID: S8MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: BMP6
Gene ID: 654
Uniprot ID: BMP6_HUMAN
Immunogen Region: 350-450
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 350-450 of human BMP6 (NP_001709.1).
Immunogen Sequence: DGPYDKQPFMVAFFKVSEVH VRTTRSASSRRRQQSRNRST QSQDVARVSSASDYNSSELK TACRKHELYVSFQDLGWQDW IIAPKGYAANYCDGECSFPL N
Post Translational Modifications Glycosylated at Asn-454. Glycosylation is crucial for recognition by the activin receptor type I/ACVR1.
Function Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation. Also plays an important role in the regulation of HAMP/hepcidin expression and iron metabolism by acting as a ligand for hemojuvelin/HJV. Also acts to promote expression of HAMP, potentially via the interaction with its receptor BMPR1A/ALK3. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target. Can also signal through non-canonical pathway such as TAZ-Hippo signaling cascade to modulate VEGF signaling by regulating VEGFR2 expression.
Protein Name Bone Morphogenetic Protein 6
Bmp-6
Vg-1-Related Protein
Vg-1-R
Vgr-1
Cellular Localisation Secreted
Alternative Antibody Names Anti-Bone Morphogenetic Protein 6 antibody
Anti-Bmp-6 antibody
Anti-Vg-1-Related Protein antibody
Anti-Vg-1-R antibody
Anti-Vgr-1 antibody
Anti-BMP6 antibody
Anti-VGR antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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