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  • 产品名称：Human NAAA (N-Acylethanolamine Acid Amidase) Sandwich ELISA Kit Ready-To-Use (STJE0017245)

  • 产品型号：STJE0017245
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human NAAA (N-Acylethanolamine Acid Amidase) Sandwich ELISA Kit Ready-To-Use (STJE0017245)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.122ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This NAAA Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: NAAA
Gene ID: 27163
Uniprot ID: NAAA_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Expressed in numerous tissues, with highest levels in liver and kidney, followed by pancreas.
Post Translational Modifications N-glycosylated. Tunicamycin treatment causes a reduction in specific activity against N-palmitoylethanolamine. A disulfide bond is seen in the crystal structure of the human protein, but the Cys residues are not conserved in rodents. Autoproteolytic cleavage at pH 4.5 gives rise to the alpha and beta subunit. Cleavage gives rise to a conformation change that activates the enzyme. The same catalytic Cys residue mediates the autoproteolytic cleavage and subsequent hydrolysis of lipid substrates (Probable).
Function Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine. Also exhibits weak hydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine.
Protein Name N-Acylethanolamine-Hydrolyzing Acid Amidase
Acid Ceramidase-Like Protein
Acylsphingosine Deacylase Naaa
N-Acylsphingosine Amidohydrolase-Like
Asah-Like Protein Cleaved Into - N-Acylethanolamine-Hydrolyzing Acid Amidase Subunit Alpha - N-Acylethanolamine-Hydrolyzing Acid Amidase Subunit Beta
Database Links Reactome: R-HSA-112310
Cellular Localisation Lysosome
Membrane
Peripheral Membrane Protein
Alternative ELISA Names N-Acylethanolamine-Hydrolyzing Acid Amidase ELISA kit
Acid Ceramidase-Like Protein ELISA kit
Acylsphingosine Deacylase Naaa ELISA kit
N-Acylsphingosine Amidohydrolase-Like ELISA kit
Asah-Like Protein Cleaved Into - N-Acylethanolamine-Hydrolyzing Acid Amidase Subunit Alpha - N-Acylethanolamine-Hydrolyzing Acid Amidase Subunit Beta ELISA kit
NAAA ELISA kit
ASAHL ELISA kit
PLT ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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