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  • 产品名称：Human NCOA3 (Nuclear Receptor Coactivator 3) Sandwich ELISA Kit (STJE0010894)

  • 产品型号：STJE0010894
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human NCOA3 (Nuclear Receptor Coactivator 3) Sandwich ELISA Kit (STJE0010894)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.117ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This NCOA3 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: NCOA3
Gene ID: 8202
Uniprot ID: NCOA3_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney.
Post Translational Modifications Acetylated by CREBBP. Acetylation occurs in the RID domain, and disrupts the interaction with nuclear receptors and regulates its function. Methylated by CARM1. Phosphorylated by IKK complex. Regulated its function. Phosphorylation at Ser-601 by CK1 promotes coactivator function.
Function Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.
Protein Name Nuclear Receptor Coactivator 3
Ncoa-3
Actr
Amplified In Breast Cancer 1 Protein
Aib-1
Cbp-Interacting Protein
Pcip
Class E Basic Helix-Loop-Helix Protein 42
Bhlhe42
Receptor-Associated Coactivator 3
Rac-3
Steroid Receptor Coactivator Protein 3
Src-3
Thyroid Hormone Receptor Activator Molecule 1
Tram-1
Database Links Reactome: R-HSA-1989781
Reactome: R-HSA-381340
Reactome: R-HSA-5617472
Reactome: R-HSA-5687128
Reactome: R-HSA-9018519
Cellular Localisation Cytoplasm
Nucleus
Mainly Cytoplasmic And Weakly Nuclear
Upon Tnf Activation And Subsequent Phosphorylation
It Translocates From The Cytoplasm To The Nucleus
Alternative ELISA Names Nuclear Receptor Coactivator 3 ELISA kit
Ncoa-3 ELISA kit
Actr ELISA kit
Amplified In Breast Cancer 1 Protein ELISA kit
Aib-1 ELISA kit
Cbp-Interacting Protein ELISA kit
Pcip ELISA kit
Class E Basic Helix-Loop-Helix Protein 42 ELISA kit
Bhlhe42 ELISA kit
Receptor-Associated Coactivator 3 ELISA kit
Rac-3 ELISA kit
Steroid Receptor Coactivator Protein 3 ELISA kit
Src-3 ELISA kit
Thyroid Hormone Receptor Activator Molecule 1 ELISA kit
Tram-1 ELISA kit
NCOA3 ELISA kit
AIB1 ELISA kit
BHLHE42 ELISA kit
RAC3 ELISA kit
TRAM1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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