产品详情
简单介绍:
Anti-BOB.1 antibody [SP92] (STJ16101452)
详情介绍:
Host: | Rabbit |
Applications: | IHC-P |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit monoclonal antibody anti-BOB.1 is suitable for use in Immunohistochemistry research applications. |
Clonality: | Monoclonal |
Clone ID: | SP92 |
Conjugation: | Unconjugated |
Isotype: | IgG1 |
Formulation: | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% sodium="" azide<="" td=""> 0.1%> |
Dilution Range: | IHC-P 1:100-1:500 |
Storage Instruction: | Store at 2-8°C upon receipt. |
Background | Oct-binding factor-1 (OBF1) , also known as BOB.1, is a B-cell-specific coactivator which has been mapped to chromosome 11q23. Expression of BOB.1/OBF.1 is restricted largely to mature B-cells, with germinal center B-cells normally staining for BOB.1.2, 3 Analyses of BOB.1/OBF.1 expression in a variety of established B-cell lines representing different stages of B-cell development has suggested a constitutive, B-cell-specific expression pattern. LP cells in nodular lymphocyte predominant Hodgkin lymphoma, because they are germinal center-derived, are consistently immunoreactive for BOB.1. Conversely, only some cases of classical Hodgkin lymphoma show BOB.1 immunoreactivity within the Hodgkin and Reed-Sternberg cells. Expression of BOB.1/OBF.1 has been reported in follicular center cell lymphoma, diffuse large B-cell lymphoma and some cases of acute myeloid leukemia. B-CLL, marginal zone lymphoma, and mantle cell lymphoma may show weak to moderate immunoreactivity. |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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