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  • 产品名称：Human NHE1 (Sodium/Hydrogen Exchanger 1) Sandwich ELISA Kit Ready-To-Use (STJE0017354)

  • 产品型号：STJE0017354
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human NHE1 (Sodium/Hydrogen Exchanger 1) Sandwich ELISA Kit Ready-To-Use (STJE0017354)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.064ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This NHE1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: SLC9A1
Gene ID: 6548
Uniprot ID: SL9A1_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Kidney and intestine.
Post Translational Modifications O-glycosylated. Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is reduced by CHP1. Phosphorylation at Thr-779 increases SLC9A1 activity. Specifically dephosphorylated at Thr-779 by PPP3CA that negatively regulates SLC9A1 activity. Phosphorylation at Ser-648 by AKT1 reduces SLC9A1 binding to CALM1. Palmitoylated.may play a major role in SLC9A1 regulation.
Function Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism. Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry. Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival. In addition, can transport lithium Li(+) and functions also as a Na(+)/Li(+) antiporter. SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs.
Protein Name Sodium/Hydrogen Exchanger 1
Apnh
Na(+/H(+ Antiporter - Amiloride-Sensitive
Na(+/H(+ Exchanger 1
Nhe-1
Solute Carrier Family 9 Member 1
Database Links Reactome: R-HSA-2160916
Reactome: R-HSA-425986
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Basolateral Cell Membrane
Localized Basolaterally In Every Epithelial Cell
Except In The Choroid Plexus Where Slc9a1 Is Expressed Luminally
Alternative ELISA Names Sodium/Hydrogen Exchanger 1 ELISA kit
Apnh ELISA kit
Na(+/H(+ Antiporter - Amiloride-Sensitive ELISA kit
Na(+/H(+ Exchanger 1 ELISA kit
Nhe-1 ELISA kit
Solute Carrier Family 9 Member 1 ELISA kit
SLC9A1 ELISA kit
APNH1 ELISA kit
NHE1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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