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  • 产品名称：Human NME1 (Non Metastatic Cells 1, Protein NM23A Expressed In) Sandwich ELISA Kit (STJE0010988)

  • 产品型号：STJE0010988
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human NME1 (Non Metastatic Cells 1, Protein NM23A Expressed In) Sandwich ELISA Kit (STJE0010988)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.059ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This NME1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: NME1
Gene ID: 4830
Uniprot ID: NDKA_HUMAN
Sample Type: serum, plasma or other biological fluids.
Tissue Specificity Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation.
Post Translational Modifications
Function Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.
Protein Name Nucleoside Diphosphate Kinase A
Ndk A
Ndp Kinase A
Granzyme A-Activated Dnase
Gaad
Metastasis Inhibition Factor Nm23
Nm23-H1
Tumor Metastatic Process-Associated Protein
Database Links Reactome: R-HSA-499943
Reactome: R-HSA-9748787
Reactome: R-HSA-9755088
Cellular Localisation Cytoplasm
Nucleus
Cell-Cycle Dependent Nuclear Localization Which Can Be Induced By Interaction With Epstein-Barr Viral Proteins Or By Degradation Of The Set Complex By Gzma
Alternative ELISA Names Nucleoside Diphosphate Kinase A ELISA kit
Ndk A ELISA kit
Ndp Kinase A ELISA kit
Granzyme A-Activated Dnase ELISA kit
Gaad ELISA kit
Metastasis Inhibition Factor Nm23 ELISA kit
Nm23-H1 ELISA kit
Tumor Metastatic Process-Associated Protein ELISA kit
NME1 ELISA kit
NDPKA ELISA kit
NM23 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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