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  • 产品名称：Human NOTCH2 (Notch Homolog 2) Sandwich ELISA Kit Ready-To-Use (STJE0017406)

  • 产品型号：STJE0017406
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human NOTCH2 (Notch Homolog 2) Sandwich ELISA Kit Ready-To-Use (STJE0017406)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.33ng/mL
Detection Limit: 0.781-50ng/mL
Short Description: This NOTCH2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: NOTCH2
Gene ID: 4853
Uniprot ID: NOTC2_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Expressed in the brain, heart, kidney, lung, skeletal muscle and liver. Ubiquitously expressed in the embryo.
Post Translational Modifications Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane. Hydroxylated by HIF1AN. Can be either O-glucosylated or O-xylosylated at Ser-613 by POGLUT1. Phosphorylated by GSK3. GSK3-mediated phosphorylation is necessary for NOTCH2 recognition by FBXW7, ubiquitination and degradation via the ubiquitin proteasome pathway.
Function Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Positively regulates self-renewal of liver cancer cells.
Protein Name Neurogenic Locus Notch Homolog Protein 2
Notch 2
Hn2 Cleaved Into - Notch 2 Extracellular Truncation
N2ecd - Notch 2 Intracellular Domain
N2icd
Database Links Reactome: R-HSA-1912399
Reactome: R-HSA-1912408
Reactome: R-HSA-1912420
Reactome: R-HSA-2197563
Reactome: R-HSA-2979096
Reactome: R-HSA-350054
Reactome: R-HSA-5083630
Reactome: R-HSA-9013695
Cellular Localisation Notch 2 Extracellular Truncation: Cell Membrane
Single-Pass Type I Membrane Protein
Notch 2 Intracellular Domain: Nucleus
Cytoplasm
Following Proteolytical Processing Nicd Is Translocated To The Nucleus
Retained At The Cytoplasm By Tcim
Alternative ELISA Names Neurogenic Locus Notch Homolog Protein 2 ELISA kit
Notch 2 ELISA kit
Hn2 Cleaved Into - Notch 2 Extracellular Truncation ELISA kit
N2ecd - Notch 2 Intracellular Domain ELISA kit
N2icd ELISA kit
NOTCH2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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