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  • 产品名称：Human NQO1 (NADH Dehydrogenase, Quinone 1) Sandwich ELISA Kit Ready-To-Use (STJE0017453)

  • 产品型号：STJE0017453
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human NQO1 (NADH Dehydrogenase, Quinone 1) Sandwich ELISA Kit Ready-To-Use (STJE0017453)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.124ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This NQO1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: NQO1
Gene ID: 1728
Uniprot ID: NQO1_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity
Post Translational Modifications
Function Flavin-containing quinone reductase that catalyzes two-electron reduction of quinones to hydroquinones using either NADH or NADPH as electron donors. In a ping-pong kinetic mechanism, the electrons are sequentially transferred from NAD(P)H to flavin cofactor and then from reduced flavin to the quinone, bypassing the formation of semiquinone and reactive oxygen species. Regulates cellular redox state primarily through quinone detoxification. Reduces components of plasma membrane redox system such as coenzyme Q and vitamin quinones, producing antioxidant hydroquinone forms. In the process may function as superoxide scavenger to prevent hydroquinone oxidation and facilitate excretion. Alternatively, can activate quinones and their derivatives by generating redox reactive hydroquinones with DNA cross-linking antitumor potential. Acts as a gatekeeper of the core 20S proteasome known to degrade proteins with unstructured regions. Upon oxidative stress, interacts with tumor suppressors TP53 and TP73 in a NADH-dependent way and inhibits their ubiquitin-independent degradation by the 20S proteasome.
Protein Name Nad(Ph Dehydrogenase Quinone 1
Azoreductase
Dt-Diaphorase
Dtd
Menadione Reductase
Nad(Ph -Quinone Oxidoreductase 1
Phylloquinone Reductase
Quinone Reductase 1
Qr1
Database Links Reactome: R-HSA-350562
Reactome: R-HSA-9818027
Cellular Localisation Cytoplasm
Cytosol
Alternative ELISA Names Nad(Ph Dehydrogenase Quinone 1 ELISA kit
Azoreductase ELISA kit
Dt-Diaphorase ELISA kit
Dtd ELISA kit
Menadione Reductase ELISA kit
Nad(Ph -Quinone Oxidoreductase 1 ELISA kit
Phylloquinone Reductase ELISA kit
Quinone Reductase 1 ELISA kit
Qr1 ELISA kit
NQO1 ELISA kit
DIA4 ELISA kit
NMOR1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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