产品详情
简单介绍:
Anti-BSCL2 antibody (265-363) (STJ116793)
详情介绍:
Host: | Rabbit |
Applications: | WB/IHC/IF |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-BSCL2 (265-363) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:1000 IHC-P 1:50-1:200 IF/ICC 1:50-1:200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | BSCL2 |
Gene ID: | 26580 |
Uniprot ID: | BSCL2_HUMAN |
Immunogen Region: | 265-363 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 265-363 of human BSCL2 (NP_116056.3). |
Immunogen Sequence: | RHRFSLQVNIRKRDNSRKEV QRRISAHQPGPEGQEESTPQ SDVTEDGESPEDPSGTEGQL SEEEKPDQQPLSGEEELEPE ASDGSGSWEDAALLTEANL |
Tissue Specificity | Expressed in motor neurons in the spinal cord and cortical neurons in the frontal lobe (at protein level). Highly expressed in brain, testis and adipose tissue. |
Function | Plays a crucial role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis. In association with LDAF1, defines the sites of LD formation in the ER. Also required for growth and maturation of small nascent LDs into larger mature LDs. Mediates the formation and/or stabilization of endoplasmic reticulum-lipid droplets (ER-LD) contacts, facilitating protein and lipid delivery from the ER into growing LDs. Regulates the maturation of ZFYVE1-positive nascent LDs and the function of the RAB18-ZFYVE1 complex in mediating the formation of ER-LD contacts. Binds anionic phospholipids including phosphatidic acid. Plays an important role in the differentiation and development of adipocytes. |
Protein Name | Seipin Bernardinelli-Seip Congenital Lipodystrophy Type 2 Protein |
Cellular Localisation | Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein Lipid Droplet Localizes At Endoplasmic Reticulum-Lipid Droplets (Er-Ld) Contact Sites |
Alternative Antibody Names | Anti-Seipin antibody Anti-Bernardinelli-Seip Congenital Lipodystrophy Type 2 Protein antibody Anti-BSCL2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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