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  • 产品名称：Human OAZ1 (Ornithine Decarboxylase Antizyme 1) Sandwich ELISA Kit Ready-To-Use (STJE0017542)

  • 产品型号：STJE0017542
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human OAZ1 (Ornithine Decarboxylase Antizyme 1) Sandwich ELISA Kit Ready-To-Use (STJE0017542)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.058ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This OAZ1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: OAZ1
Gene ID: 4946
Uniprot ID: OAZ1_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications
Function Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC. Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol.
Protein Name Ornithine Decarboxylase Antizyme 1
Az1
Odc-Az
Database Links Reactome: R-HSA-350562
Cellular Localisation
Alternative ELISA Names Ornithine Decarboxylase Antizyme 1 ELISA kit
Az1 ELISA kit
Odc-Az ELISA kit
OAZ1 ELISA kit
OAZ ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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