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  • 产品名称：Human OGDH (Oxoglutarate Dehydrogenase) Sandwich ELISA Kit (STJE0011177)

  • 产品型号：STJE0011177
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human OGDH (Oxoglutarate Dehydrogenase) Sandwich ELISA Kit (STJE0011177)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.59ng/mL
Detection Limit: 1.56-100ng/mL
Short Description: This OGDH Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: OGDH
Gene ID: 4967
Uniprot ID: ODO1_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity
Post Translational Modifications
Function 2-oxoglutarate dehydrogenase (E1o) component of the 2-oxoglutarate dehydrogenase complex (OGDHC). Participates in the first step, rate limiting for the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) catalyzed by the whole OGDHC. Catalyzes the irreversible decarboxylation of 2-oxoglutarate (alpha-ketoglutarate) via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST). Plays a key role in the Krebs (citric acid) cycle, which is a common pathway for oxidation of fuel molecules, including carbohydrates, fatty acids, and amino acids. Can catalyze the decarboxylation of 2-oxoadipate in vitro, but at a much lower rate than 2-oxoglutarate. Mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A.
Protein Name 2-Oxoglutarate Dehydrogenase Complex Component E1
E1o
Ogdc-E1
Ogdh-E1
2-Oxoglutarate Dehydrogenase - Mitochondrial
Alpha-Ketoglutarate Dehydrogenase
Alpha-Kgdh-E1
Thiamine Diphosphate
Thdp-Dependent 2-Oxoglutarate Dehydrogenase
Database Links Reactome: R-HSA-389661
Reactome: R-HSA-71064
Reactome: R-HSA-71403
Cellular Localisation Mitochondrion
Nucleus
Mainly Localizes In The Mitochondrion
A Small Fraction Localizes To The Nucleus
Where The 2-Oxoglutarate Dehydrogenase Complex Is Required For Histone Succinylation
Alternative ELISA Names 2-Oxoglutarate Dehydrogenase Complex Component E1 ELISA kit
E1o ELISA kit
Ogdc-E1 ELISA kit
Ogdh-E1 ELISA kit
2-Oxoglutarate Dehydrogenase - Mitochondrial ELISA kit
Alpha-Ketoglutarate Dehydrogenase ELISA kit
Alpha-Kgdh-E1 ELISA kit
Thiamine Diphosphate ELISA kit
Thdp-Dependent 2-Oxoglutarate Dehydrogenase ELISA kit
OGDH ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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