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  • 产品名称：Human PAK4 (p21 Protein Activated Kinase 4) Sandwich ELISA Kit Ready-To-Use (STJE0017649)

  • 产品型号：STJE0017649
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human PAK4 (p21 Protein Activated Kinase 4) Sandwich ELISA Kit Ready-To-Use (STJE0017649)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.065ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This PAK4 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: PAK4
Gene ID: 10298
Uniprot ID: PAK4_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Highest expression in prostate, testis and colon.
Post Translational Modifications Autophosphorylated on serine residues when activated by CDC42/p21 (Ref.32). Phosphorylated on tyrosine residues upon stimulation of FGFR2. Methylated by SETD6. Polyubiquitinated, leading to its proteasomal degradation.
Function Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.
Protein Name Serine/Threonine-Protein Kinase Pak 4
P21-Activated Kinase 4
Pak-4
Database Links Reactome: R-HSA-428540
Reactome: R-HSA-9013148
Reactome: R-HSA-9013149
Reactome: R-HSA-9013404
Reactome: R-HSA-9013406
Reactome: R-HSA-9013407
Reactome: R-HSA-9013408
Reactome: R-HSA-9013409
Reactome: R-HSA-9013420
Reactome: R-HSA-9013423
Reactome: R-HSA-9013424
Cellular Localisation Cytoplasm
Seems To Shuttle Between Cytoplasmic Compartments Depending On The Activating Effector
For Example
Can Be Found On The Cell Periphery After Activation Of Growth-Factor Or Integrin-Mediated Signaling Pathways
Alternative ELISA Names Serine/Threonine-Protein Kinase Pak 4 ELISA kit
P21-Activated Kinase 4 ELISA kit
Pak-4 ELISA kit
PAK4 ELISA kit
KIAA1142 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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