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  • 产品名称：Human PAM (Peptidylglycine Alpha Amidating Monooxygenase) Sandwich ELISA Kit (STJE0011266)

  • 产品型号：STJE0011266
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human PAM (Peptidylglycine Alpha Amidating Monooxygenase) Sandwich ELISA Kit (STJE0011266)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 13.5pg/mL
Detection Limit: 31.2-2000pg/mL
Short Description: This PAM Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: PAM
Gene ID: 5066
Uniprot ID: AMD_HUMAN
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications
Function Bifunctional enzyme that catalyzes the post-translational modification of inactive peptidylglycine precursors to the corresponding bioactive alpha-amidated peptides, a terminal modification in biosynthesis of many neural and endocrine peptides. Alpha-amidation involves two sequential reactions, both of which are catalyzed by separate catalytic domains of the enzyme. The first step, catalyzed by peptidyl alpha-hydroxylating monooxygenase (PHM) domain, is the copper-, ascorbate-, and O2- dependent stereospecific hydroxylation (with S stereochemistry) at the alpha-carbon (C-alpha) of the C-terminal glycine of the peptidylglycine substrate. The second step, catalyzed by the peptidylglycine amidoglycolate lyase (PAL) domain, is the zinc-dependent cleavage of the N-C-alpha bond, producing the alpha-amidated peptide and glyoxylate. Similarly, catalyzes the two-step conversion of an N-fatty acylglycine to a primary fatty acid amide and glyoxylate.
Protein Name Peptidyl-Glycine Alpha-Amidating Monooxygenase
Pam Includes - Peptidylglycine Alpha-Hydroxylating Monooxygenase
Phm - Peptidyl-Alpha-Hydroxyglycine Alpha-Amidating Lyase
Peptidylamidoglycolate Lyase
Pal
Database Links
Cellular Localisation Cytoplasmic Vesicle
Secretory Vesicle Membrane
Single-Pass Membrane Protein
Secretory Granules
Isoform 1: Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Membrane
Isoform 3: Secreted
Secreted From Secretory Granules
Isoform 4: Secreted
Alternative ELISA Names Peptidyl-Glycine Alpha-Amidating Monooxygenase ELISA kit
Pam Includes - Peptidylglycine Alpha-Hydroxylating Monooxygenase ELISA kit
Phm - Peptidyl-Alpha-Hydroxyglycine Alpha-Amidating Lyase ELISA kit
Peptidylamidoglycolate Lyase ELISA kit
Pal ELISA kit
PAM ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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