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  • 产品名称：Anti-C14orf169/NO66 antibody (Internal) (STJ71098)

  • 产品型号：STJ71098-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-C14orf169/NO66 antibody (Internal) (STJ71098)
详情介绍：
Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-C14orf169/NO66 (Internal) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-0.3-1µg/ml
ELISA-antibody detection limit dilution 1:64000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: RIOX1
Gene ID: 79697
Uniprot ID: RIOX1_HUMAN
Immunogen Region: Internal
Accession Number: NP_078920.2
Immunogen Sequence: GAQHSDSKDPR
Function Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation. Also catalyzes demethylation of non-histone proteins, such as CGAS: demethylation of monomethylated CGAS promotes interaction between CGAS and PARP1, followed by PARP1 inactivation. Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216', thereby playing a role in ribosome biogenesis. Participates in MYC-induced transcriptional activation.
Protein Name Ribosomal Oxygenase 1
60s Ribosomal Protein L8 Histidine Hydroxylase
Bifunctional Lysine-Specific Demethylase And Histidyl-Hydroxylase No66
Myc-Associated Protein With Jmjc Domain
Nucleolar Protein 66
Hsno66
Ribosomal Oxygenase No66
Rox
Cellular Localisation Nucleus
Nucleolus
Nucleoplasm
Granular Part Of Nucleoli
Nucleoplasmic Foci
Some Of Them Associated With Nucleoli
Alternative Antibody Names Anti-Ribosomal Oxygenase 1 antibody
Anti-60s Ribosomal Protein L8 Histidine Hydroxylase antibody
Anti-Bifunctional Lysine-Specific Demethylase And Histidyl-Hydroxylase No66 antibody
Anti-Myc-Associated Protein With Jmjc Domain antibody
Anti-Nucleolar Protein 66 antibody
Anti-Hsno66 antibody
Anti-Ribosomal Oxygenase No66 antibody
Anti-Rox antibody
Anti-RIOX1 antibody
Anti-C14orf169 antibody
Anti-MAPJD antibody
Anti-NO66 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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