产品详情
简单介绍：
Anti-C14orf68 antibody (242-254) (STJ71088)
详情介绍：
| Host: | Goat |
| Applications: | Pep-ELISA/IHC |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Goat polyclonal antibody anti-C14orf68 (242-254) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | IHC-Recommended concentration, 2.5µg/ml ELISA-antibody detection limit dilution 1:32000. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | SLC25A47 |
| Gene ID: | 283600 |
| Uniprot ID: | S2547_HUMAN |
| Immunogen Region: | 242-254 |
| Accession Number: | NP_997000.2 |
| Immunogen Sequence: | KSRLQADGQGQRR |
| Function | Mitochondrial NAD(+) transporter that acts as a 'metabolic gate' in hepatic lipogenesis. Provides NAD(+) substrate to mitochondrial SIRT3 deacetylase and enables its NAD(+)-dependent activities in mitochondrial energy metabolism. This triggers downstream activation of PRKAA1/AMPK-alpha signaling cascade that negatively regulates sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. May transport other mitochondrial metabolites having an aromatic nucleotide and phosphate groups, such as acetyl-CoA. Does not transport amino acids. The transport mechanism remains to be elucidated. |
| Protein Name | Solute Carrier Family 25 Member 47 Hepatocellular Carcinoma Down-Regulated Mitochondrial Carrier Protein Mitochondrial Nad(+ Transporter Slc25a47 |
| Cellular Localisation | Mitochondrion Inner Membrane Multi-Pass Membrane Protein Mitochondrion Outer Membrane |
| Alternative Antibody Names | Anti-Solute Carrier Family 25 Member 47 antibody Anti-Hepatocellular Carcinoma Down-Regulated Mitochondrial Carrier Protein antibody Anti-Mitochondrial Nad(+ Transporter Slc25a47 antibody Anti-SLC25A47 antibody Anti-C14orf68 antibody Anti-HDMCP antibody Anti-HMFN1655 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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