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  • 产品名称：Anti-CD71 antibody [DF1513] (STJA0003869)

  • 产品型号：STJA0003869-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CD71 antibody [DF1513] (STJA0003869)
详情介绍：
Host: Mouse
Applications: WB/IHC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-CD71 is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: DF1513
Conjugation: Unconjugated
Isotype: IgG1
Formulation: 100 ul in PBS
Purification: Protein G purified culture supernatant.
Dilution Range: WB 1:1000
IHC 1:100
ICC
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TFRC
Gene ID: 7037
Uniprot ID: TFR1_HUMAN
Immunogen: KG1 cell line
Function Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway. When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion. When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2. (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus.
Protein Name Transferrin Receptor Protein 1
Tr
Tfr
Tfr1
Trfr
T9
P90
Cd Antigen Cd71 Cleaved Into - Transferrin Receptor Protein 1 - Serum Form
Stfr
Database Links Reactome: R-HSA-432722
Reactome: R-HSA-8856825
Reactome: R-HSA-8856828
Reactome: R-HSA-8980692
Reactome: R-HSA-9013026
Reactome: R-HSA-9013106
Reactome: R-HSA-9013148
Reactome: R-HSA-9013149
Reactome: R-HSA-9013404
Reactome: R-HSA-9013406
Reactome: R-HSA-9013407
Reactome: R-HSA-9013408
Reactome: R-HSA-9013409
Reactome: R-HSA-9013423
Reactome: R-HSA-917977
Reactome: R-HSA-9696270
Reactome: R-HSA-9696273
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Melanosome
Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv
Transferrin Receptor Protein 1
Serum Form: Secreted
Alternative Antibody Names Anti-Transferrin Receptor Protein 1 antibody
Anti-Tr antibody
Anti-Tfr antibody
Anti-Tfr1 antibody
Anti-Trfr antibody
Anti-T9 antibody
Anti-P90 antibody
Anti-Cd Antigen Cd71 Cleaved Into - Transferrin Receptor Protein 1 - Serum Form antibody
Anti-Stfr antibody
Anti-TFRC antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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