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  • 产品名称：Anti-C1orf112 antibody (STJA0004822)

  • 产品型号：STJA0004822
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-C1orf112 antibody (STJA0004822)
详情介绍：
Host: Rabbit
Applications: IHC/ELISA
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Uncharacterized Protein C1orf112 is suitable for use in Immunohistochemistry and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Purification: Antigen affinity purification
Concentration: 1.92 mg/mL
Dilution Range: IHC 1:100-1:300
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Gene Symbol: FIRRM
Gene ID: 55732
Uniprot ID: FIRRM_HUMAN
Immunogen: Fusion protein of human C1orf112
Post Translational Modifications Phosphorylation at Ser-43 by PLK1 strengthens FIRRM-PLK1 interaction. Phosphorylation at Ser-744 by PLK1 negatively regulates its interaction with PPP1CC.
Function Regulates PLK1 kinase activity at kinetochores and promotes faithful chromosome segregation in prometaphase by bridging kinase and phosphatase activities. Phosphorylation of FIRRM by PLK1 negatively regulates its interaction with the phosphatase, PPP1CC, thus creating a negative feedback loop for maintaining proper PLK1 kinase activity during mitosis. In complex with FIGL1 may regulate homologous recombination.
Protein Name Fignl1-Interacting Regulator Of Recombination And Mitosis
Fidgetin-Like-1 Interacting Protein
Flip
Polo1-Associating Protein
Cellular Localisation Chromosome
Centromere
Kinetochore
Nucleus
Midbody
Cytoplasm
Cytoskeleton
Spindle
Exhibits Cell-Cycle-Dependent Distribution During Mitosis
Detected In The Nucleus In Interphase
Colocalizes With Plk1 To The Centromeres In A Nearby Prometaphase Cells
Relocates To The Central Spindle In Anaphase And To The Midbody In Telophase Cells
Alternative Antibody Names Anti-Fignl1-Interacting Regulator Of Recombination And Mitosis antibody
Anti-Fidgetin-Like-1 Interacting Protein antibody
Anti-Flip antibody
Anti-Polo1-Associating Protein antibody
Anti-FIRRM antibody
Anti-APOLO1 antibody
Anti-C1orf112 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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