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  • 产品名称：Anti-CD95 antibody [B-R18] (STJ16100141)

  • 产品型号：STJ16100141
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CD95 antibody [B-R18] (STJ16100141)
详情介绍：
Host: Mouse
Applications: FC/IF/IHC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-CD95 is suitable for use in Flow Cytometry, Immunofluorescence and Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: B-R18
Conjugation: Unconjugated
Isotype: IgG1k
Formulation: PBS with 0.02% Sodium Azide.
Purification: Affinity purified from tissue culture.
Concentration: Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL.
Dilution Range: Flow cytometry (0, 5-1, 0 µg/million cells in 0, 1 ml). Immunofluorescence (0, 5-1, 0 µg/ml). Immunohistology (1-2 µg/ml for 30 min at RT; an appropriate antigen retrieval method for staining of formalin-fixed tissues has not been established to date
Storage Instruction: Store for up to 1 year at 2-8°C upon receipt.
Gene Symbol: FASLG
Gene ID: 356
Uniprot ID: TNFL6_HUMAN
Immunogen: A BALB/c mouse was immunized with recombinant Fas antigen. Fusion partner: P3-X63-Ag8.653.
Post Translational Modifications The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form undergoes two successive intramembrane proteolytic cleavages. The first one is processed by ADAM10 producing an N-terminal fragment, which lacks the receptor-binding extracellular domain. This ADAM10-processed FasL (FasL APL) remnant form is still membrane anchored and further processed by SPPL2A that liberates the FasL intracellular domain (FasL ICD). FasL shedding by ADAM10 is a prerequisite for subsequent intramembrane cleavage by SPPL2A in T-cells. N-glycosylated. Glycosylation enhances apoptotic activity. Phosphorylated by FGR on tyrosine residues.this is required for ubiquitination and subsequent internalization. Monoubiquitinated.
Function Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. Tumor necrosis factor ligand superfamily member 6, soluble form: Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways. Can induce apoptosis but does not appear to be essential for this process. FasL intracellular domain: Cytoplasmic form induces gene transcription inhibition.
Protein Name Tumor Necrosis Factor Ligand Superfamily Member 6
Apoptosis Antigen Ligand
Aptl
Cd95 Ligand
Cd95-L
Fas Antigen Ligand
Fas Ligand
Fasl
Cd Antigen Cd178 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 6 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 6 - Soluble Form
Receptor-Binding Fasl Ectodomain
Soluble Fas Ligand
Sfasl - Adam10-Processed Fasl Form
Apl - Fasl Intracellular Domain
Fasl Icd
Sppl2a-Processed Fasl Form
Spa
Database Links Reactome: R-HSA-140534
Reactome: R-HSA-3371378
Reactome: R-HSA-5213460
Reactome: R-HSA-5218900
Reactome: R-HSA-6785807
Reactome: R-HSA-69416
Reactome: R-HSA-75157
Reactome: R-HSA-8862803
Reactome: R-HSA-9614657
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Cytoplasmic Vesicle Lumen
Lysosome Lumen
Is Internalized Into Multivesicular Bodies Of Secretory Lysosomes After Phosphorylation By Fgr And Monoubiquitination
Colocalizes With The Sppl2a Protease At The Cell Membrane
Tumor Necrosis Factor Ligand Superfamily Member 6
Soluble Form: Secreted
May Be Released Into The Extracellular Fluid By Cleavage From The Cell Surface
Fasl Intracellular Domain: Nucleus
The Fasl Icd Cytoplasmic Form Is Translocated Into The Nucleus
Alternative Antibody Names Anti-Tumor Necrosis Factor Ligand Superfamily Member 6 antibody
Anti-Apoptosis Antigen Ligand antibody
Anti-Aptl antibody
Anti-Cd95 Ligand antibody
Anti-Cd95-L antibody
Anti-Fas Antigen Ligand antibody
Anti-Fas Ligand antibody
Anti-Fasl antibody
Anti-Cd Antigen Cd178 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 6 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 6 - Soluble Form antibody
Anti-Receptor-Binding Fasl Ectodomain antibody
Anti-Soluble Fas Ligand antibody
Anti-Sfasl - Adam10-Processed Fasl Form antibody
Anti-Apl - Fasl Intracellular Domain antibody
Anti-Fasl Icd antibody
Anti-Sppl2a-Processed Fasl Form antibody
Anti-Spa antibody
Anti-FASLG antibody
Anti-APT1LG1 antibody
Anti-CD95L antibody
Anti-FASL antibody
Anti-TNFSF6 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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