Name: Human PLCg1 (Phospholipase C Gamma 1) Sandwich ELISA Kit (STJE0011539)
Brand: ST john's laboratory
SKU: STJE0011539

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产品名称：Human PLCg1 (Phospholipase C Gamma 1) Sandwich ELISA Kit (STJE0011539)
产品型号：STJE0011539
产品厂商：ST john's laboratory
产品文档：

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简单介绍：

Human PLCg1 (Phospholipase C Gamma 1) Sandwich ELISA Kit (STJE0011539)

详情介绍：

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.068ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This PLCg1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	PLCG1
Gene ID:	5335
Uniprot ID:	PLCG1_HUMAN
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity
Post Translational Modifications	Tyrosine phosphorylated in response to signaling via activated FLT3, KIT and PDGFRA. Tyrosine phosphorylated by activated FGFR1, FGFR2, FGFR3 and FGFR4. Tyrosine phosphorylated by activated FLT1 and KDR. Tyrosine phosphorylated by activated PDGFRB. The receptor-mediated activation of PLCG1 involves its phosphorylation by tyrosine kinases, in response to ligation of a variety of growth factor receptors and immune system receptors. For instance, SYK phosphorylates and activates PLCG1 in response to ligation of the B-cell receptor. May be dephosphorylated by PTPRJ. Phosphorylated by ITK and TXK on Tyr-783 upon TCR activation in T-cells. Ubiquitinated by CBLB in activated T-cells.
Function	Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.
Protein Name	1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Gamma-1 Plc-148 Phosphoinositide Phospholipase C-Gamma-1 Phospholipase C-Ii Plc-Ii Phospholipase C-Gamma-1 Plc-Gamma-1
Database Links	Reactome: R-HSA-1169408 Reactome: R-HSA-1236382 Reactome: R-HSA-1251932 Reactome: R-HSA-1489509 Reactome: R-HSA-167021 Reactome: R-HSA-1855204 Reactome: R-HSA-186763 Reactome: R-HSA-201556 Reactome: R-HSA-202433 Reactome: R-HSA-2029485 Reactome: R-HSA-210990 Reactome: R-HSA-212718 Reactome: R-HSA-2424491 Reactome: R-HSA-2871796 Reactome: R-HSA-2871809 Reactome: R-HSA-418890 Reactome: R-HSA-5218921 Reactome: R-HSA-5637810 Reactome: R-HSA-5654219 Reactome: R-HSA-5654221 Reactome: R-HSA-5654227 Reactome: R-HSA-5654228 Reactome: R-HSA-5655253 Reactome: R-HSA-5655291 Reactome: R-HSA-5655302 Reactome: R-HSA-5655332 Reactome: R-HSA-8853659 Reactome: R-HSA-9026527 Reactome: R-HSA-9027277 Reactome: R-HSA-9034793 Reactome: R-HSA-9664323 Reactome: R-HSA-9664565 Reactome: R-HSA-9665348 Reactome: R-HSA-9665686 Reactome: R-HSA-9725370
Cellular Localisation	Cell Projection Lamellipodium Ruffle Rapidly Redistributed To Ruffles And Lamellipodia Structures In Response To Epidermal Growth Factor (Egf) Treatment
Alternative ELISA Names	1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Gamma-1 ELISA kit Plc-148 ELISA kit Phosphoinositide Phospholipase C-Gamma-1 ELISA kit Phospholipase C-Ii ELISA kit Plc-Ii ELISA kit Phospholipase C-Gamma-1 ELISA kit Plc-Gamma-1 ELISA kit PLCG1 ELISA kit PLC1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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产品名称：Human PLCg1 (Phospholipase C Gamma 1) Sandwich ELISA Kit (STJE0011539)