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  • 产品名称：Human PRNP (Prion Protein) Sandwich ELISA Kit (STJE0011674)

  • 产品型号：STJE0011674
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human PRNP (Prion Protein) Sandwich ELISA Kit (STJE0011674)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.117ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This PRNP Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: PRNP
Gene ID: 5621
Uniprot ID: PRIO_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity
Post Translational Modifications The glycosylation pattern (the amount of mono-, di- and non-glycosylated forms or glycoforms) seems to differ in normal and CJD prion.
Function Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.
Protein Name Major Prion Protein
Prp
Ascr
Prp27-30
Prp33-35c
Cd Antigen Cd230
Database Links
Reactome: R-HSA-419037
Reactome: R-HSA-9609523
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Golgi Apparatus
Targeted To Lipid Rafts Via Association With The Heparan Sulfate Chains Of Gpc1
Colocates
In The Presence Of Cu(2+)
To Vesicles In Para- And Perinuclear Regions
Where Both Proteins Undergo Internalization
Heparin Displaces Prnp From Lipid Rafts And Promotes Endocytosis
Alternative ELISA Names Major Prion Protein ELISA kit
Prp ELISA kit
Ascr ELISA kit
Prp27-30 ELISA kit
Prp33-35c ELISA kit
Cd Antigen Cd230 ELISA kit
PRNP ELISA kit
ALTPRP ELISA kit
PRIP ELISA kit
PRP ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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