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  • 产品名称：Human PTGS1 (Prostaglandin Endoperoxide Synthase 1) Sandwich ELISA Kit Ready-To-Use (STJE0018120)

  • 产品型号：STJE0018120
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human PTGS1 (Prostaglandin Endoperoxide Synthase 1) Sandwich ELISA Kit Ready-To-Use (STJE0018120)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.241ng/mL
Detection Limit: 0.625-40ng/mL
Short Description: This PTGS1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: PTGS1
Gene ID: 5742
Uniprot ID: PGH1_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications
Function Dual cyclooxygenase and peroxidase that plays an important role in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate, AA, C20:4(n-6)), with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates AA to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide prostaglandin H2 (PGH2), the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells (Probable). Can also use linoleate (LA, (9Z,12Z)-octadecadienoate, C18:2(n-6)) as substrate and produce hydroxyoctadecadienoates (HODEs) in a regio- and stereospecific manner, being (9R)-HODE ((9R)-hydroxy-(10E,12Z)-octadecadienoate) and (13S)-HODE ((13S)-hydroxy-(9Z,11E)-octadecadienoate) its major products.
Protein Name Prostaglandin G/H Synthase 1
Cyclooxygenase-1
Cox-1
Prostaglandin H2 Synthase 1
Pgh Synthase 1
Pghs-1
Phs 1
Prostaglandin-Endoperoxide Synthase 1
Database Links Reactome: R-HSA-140180
Reactome: R-HSA-2162123
Cellular Localisation Microsome Membrane
Peripheral Membrane Protein
Endoplasmic Reticulum Membrane
Alternative ELISA Names Prostaglandin G/H Synthase 1 ELISA kit
Cyclooxygenase-1 ELISA kit
Cox-1 ELISA kit
Prostaglandin H2 Synthase 1 ELISA kit
Pgh Synthase 1 ELISA kit
Pghs-1 ELISA kit
Phs 1 ELISA kit
Prostaglandin-Endoperoxide Synthase 1 ELISA kit
PTGS1 ELISA kit
COX1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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