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  • 产品名称：Anti-CDK12 antibody (1-300) (STJ117094)

  • 产品型号：STJ117094
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CDK12 antibody (1-300) (STJ117094)
详情介绍：
Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CDK12 (1-300) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
IHC-P 1:100-1:500
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CDK12
Gene ID: 51755
Uniprot ID: CDK12_HUMAN
Immunogen Region: 1-300
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CDK12 (NP_057591.2).
Immunogen Sequence: MPNSERHGGKKDGSGGASGT LQPSSGGGSSNSRERHRLVS KHKRHKSKHSKDMGLVTPEA ASLGTVIKPLVEYDDISSDS DTFSDDMAFKLDRRENDERR GSDRSDRLHKHRHHQHRRSR DLLKAKQTEKEKSQEVSSKS GSMKDRISGSSKRSNEETDD YGKAQVAKSSSKESRSSKLH KEKTRKERELKSGHKDRSKS HRKRETPKSYKTVDSPKRRS RSPHRKWSDSSKQDDSPSG
Tissue Specificity Widely expressed.
Post Translational Modifications Phosphorylation at Thr-893 increases kinase activity.
Function Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
Protein Name Cyclin-Dependent Kinase 12
Cdc2-Related Kinase - Arginine/Serine-Rich
Crkrs
Cell Division Cycle 2-Related Protein Kinase 7
Cdc2-Related Protein Kinase 7
Cell Division Protein Kinase 12
Hcdk12
Database Links Reactome: R-HSA-6796648
Cellular Localisation Nucleus
Nucleus Speckle
Colocalized With Nuclear Speckles Throughout Interphase
Alternative Antibody Names Anti-Cyclin-Dependent Kinase 12 antibody
Anti-Cdc2-Related Kinase - Arginine/Serine-Rich antibody
Anti-Crkrs antibody
Anti-Cell Division Cycle 2-Related Protein Kinase 7 antibody
Anti-Cdc2-Related Protein Kinase 7 antibody
Anti-Cell Division Protein Kinase 12 antibody
Anti-Hcdk12 antibody
Anti-CDK12 antibody
Anti-CRK7 antibody
Anti-CRKRS antibody
Anti-KIAA0904 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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