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  • 产品名称：Human PTPN6 (Protein Tyrosine Phosphatase, Non Receptor Type 6) Sandwich ELISA Kit Ready-To-Use (STJE0018153)

  • 产品型号：STJE0018153
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human PTPN6 (Protein Tyrosine Phosphatase, Non Receptor Type 6) Sandwich ELISA Kit Ready-To-Use (STJE0018153)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.105ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This PTPN6 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: PTPN6
Gene ID: 5777
Uniprot ID: PTN6_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.
Post Translational Modifications Phosphorylated on tyrosine residues. Binding of KITLG/SCF to KIT increases tyrosine phosphorylation. Phosphorylation at Tyr-564 enhances phosphatase activity.
Function Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.
Protein Name Tyrosine-Protein Phosphatase Non-Receptor Type 6
Hematopoietic Cell Protein-Tyrosine Phosphatase
Protein-Tyrosine Phosphatase 1c
Ptp-1c
Protein-Tyrosine Phosphatase Shp-1
Sh-Ptp1
Database Links Reactome: R-HSA-114604
Reactome: R-HSA-1433559
Reactome: R-HSA-201556
Reactome: R-HSA-210990
Reactome: R-HSA-388841
Reactome: R-HSA-389948
Reactome: R-HSA-391160
Reactome: R-HSA-432142
Reactome: R-HSA-512988
Reactome: R-HSA-5690714
Reactome: R-HSA-6798695
Reactome: R-HSA-877300
Reactome: R-HSA-877312
Reactome: R-HSA-9008059
Reactome: R-HSA-909733
Reactome: R-HSA-912526
Reactome: R-HSA-912694
Reactome: R-HSA-9705671
Reactome: R-HSA-982772
Reactome: R-HSA-983695
Cellular Localisation Cytoplasm
Nucleus
In Neurons
Translocates Into The Nucleus After Treatment With Angiotensin Ii
Shuttles Between The Cytoplasm And Nucleus Via Its Association With Pdpk1
Alternative ELISA Names Tyrosine-Protein Phosphatase Non-Receptor Type 6 ELISA kit
Hematopoietic Cell Protein-Tyrosine Phosphatase ELISA kit
Protein-Tyrosine Phosphatase 1c ELISA kit
Ptp-1c ELISA kit
Protein-Tyrosine Phosphatase Shp-1 ELISA kit
Sh-Ptp1 ELISA kit
PTPN6 ELISA kit
HCP ELISA kit
PTP1C ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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