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  • 产品名称：Anti-CDK8 antibody (365-464) (STJ27494)

  • 产品型号：STJ27494
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CDK8 antibody (365-464) (STJ27494)
详情介绍：
Host: Rabbit
Applications: WB/IP
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CDK8 (365-464) is suitable for use in Western Blot and Immunoprecipitation research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IP 1:50-1:100
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CDK8
Gene ID: 1024
Uniprot ID: CDK8_HUMAN
Immunogen Region: 365-464
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 365-464 of human CDK8 (NP_001251.1).
Immunogen Sequence: DDKGDKKNQQQQQGNNHTNG TGHPGNQDSSHTQGPPLKKV RVVPPTTTSGGLIMTSDYQR SNPHAAYPNPGPSTSQPQSS MGYSATSQQPPQYSHQTHRY
Function Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation.
Protein Name Cyclin-Dependent Kinase 8
Cell Division Protein Kinase 8
Mediator Complex Subunit Cdk8
Mediator Of Rna Polymerase Ii Transcription Subunit Cdk8
Protein Kinase K35
Database Links Reactome: R-HSA-1989781
Reactome: R-HSA-2122947
Reactome: R-HSA-212436
Reactome: R-HSA-2173796
Reactome: R-HSA-2644606
Reactome: R-HSA-2894862
Reactome: R-HSA-381340
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Cyclin-Dependent Kinase 8 antibody
Anti-Cell Division Protein Kinase 8 antibody
Anti-Mediator Complex Subunit Cdk8 antibody
Anti-Mediator Of Rna Polymerase Ii Transcription Subunit Cdk8 antibody
Anti-Protein Kinase K35 antibody
Anti-CDK8 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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