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  • 产品名称：Anti-CDKN2A antibody (57-156) [S3MR] (STJ113253)

  • 产品型号：STJ113253
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CDKN2A antibody (57-156) [S3MR] (STJ113253)
详情介绍：
Host: Rabbit
Applications: WB/IHC/IF
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-CDKN2A/p16INK4a (57-156) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.
Clonality: Monoclonal
Clone ID: S3MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC-P 1:50-1:200
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CDKN2A
Gene ID: 1029
Uniprot ID: CDN2A_HUMAN
Immunogen Region: 57-156
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 57-156 of human CDKN2A/p16INK4a (P42771).
Immunogen Sequence: ARVAELLLLHGAEPNCADPA TLTRPVHDAAREGFLDTLVV LHRAGARLDVRDAWGRLPVD LAEELGHRDVARYLRAAAGG TRGSNHARIDAAEGPSDIPD
Tissue Specificity Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific.
Post Translational Modifications Phosphorylation seems to increase interaction with CDK4.
Function Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.
Protein Name Cyclin-Dependent Kinase Inhibitor 2a
Cyclin-Dependent Kinase 4 Inhibitor A
Cdk4i
Multiple Tumor Suppressor 1
Mts-1
P16-Ink4a
P16-Ink4
P16ink4a
Database Links Reactome: R-HSA-111471
Reactome: R-HSA-2559580
Reactome: R-HSA-2559585
Reactome: R-HSA-3108214
Reactome: R-HSA-3232118
Reactome: R-HSA-6804757
Reactome: R-HSA-69541
Reactome: R-HSA-8941858
Reactome: R-HSA-9645722
Reactome: R-HSA-9646303
Reactome: R-HSA-9646304
Reactome: R-HSA-9759194
Reactome: R-HSA-2559582
Reactome: R-HSA-69231
Reactome: R-HSA-8853884
Reactome: R-HSA-9630791
Reactome: R-HSA-9630794
Reactome: R-HSA-9632697
Reactome: R-HSA-9632700
Cellular Localisation Cytoplasm
Nucleus
Alternative Antibody Names Anti-Cyclin-Dependent Kinase Inhibitor 2a antibody
Anti-Cyclin-Dependent Kinase 4 Inhibitor A antibody
Anti-Cdk4i antibody
Anti-Multiple Tumor Suppressor 1 antibody
Anti-Mts-1 antibody
Anti-P16-Ink4a antibody
Anti-P16-Ink4 antibody
Anti-P16ink4a antibody
Anti-CDKN2A antibody
Anti-CDKN2 antibody
Anti-MTS1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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