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  • 产品名称：Anti-CALCOCO1 antibody (462-691) (STJ110294)

  • 产品型号：STJ110294
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CALCOCO1 antibody (462-691) (STJ110294)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CALCOCO1 (462-691) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CALCOCO1
Gene ID: 57658
Uniprot ID: CACO1_HUMAN
Immunogen Region: 462-691
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 462-691 of human CALCOCO1 (NP_065949.1).
Immunogen Sequence: LVQLSESKRELTELRSALRV LQKEKEQLQEEKQELLEYMR KLEARLEKVADEKWNEDATT EDEEAAVGLSCPAALTDSED ESPEDMRLPPYGLCERGDPG SSPAGPREASPLVVISQPAP ISPHLSGPAEDSSSDSEAED EKSVLMAAVQSGGEEANLLL PELGSAFYDMASGFTVGTLS ETSTGGPATPTWKECPICKE RFPAESDKDALEDHMDGHFF FSTQDPFTFE
Function Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions. In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells. Seems to enhance inorganic pyrophosphatase thus activating phosphogluomutase (PMG). Probably functions as component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth.
Protein Name Calcium-Binding And Coiled-Coil Domain-Containing Protein 1
Calphoglin
Coiled-Coil Coactivator Protein
Sarcoma Antigen Ny-Sar-3
Cellular Localisation Cytoplasm
Nucleus
Shuttles Between Nucleus And Cytoplasm
Alternative Antibody Names Anti-Calcium-Binding And Coiled-Coil Domain-Containing Protein 1 antibody
Anti-Calphoglin antibody
Anti-Coiled-Coil Coactivator Protein antibody
Anti-Sarcoma Antigen Ny-Sar-3 antibody
Anti-CALCOCO1 antibody
Anti-KIAA1536 antibody
Anti-PP13275 antibody
Anti-UNQ2436 antibody
Anti-PRO4996 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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