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  • 产品名称：Human RAB7A (RAB7A, Member RAS Oncogene Family) Sandwich ELISA Kit (STJE0011805)

  • 产品型号：STJE0011805
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human RAB7A (RAB7A, Member RAS Oncogene Family) Sandwich ELISA Kit (STJE0011805)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.113ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This RAB7A Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: RAB7A
Gene ID: 7879
Uniprot ID: RAB7A_HUMAN
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Widely expressed.high expression found in skeletal muscle.
Post Translational Modifications Deubiquitination at Lys-191 and Lys-194 by USP32.
Function Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins playing a key role in the regulation of endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA. Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway. Required for the exosomal release of SDCBP, CD63 and syndecan. Required for vesicular trafficking and cell surface expression of ACE2. May play a role in PRPH neuronal intermediate filament assembly.
Protein Name Ras-Related Protein Rab-7a
Database Links Reactome: R-HSA-2132295
Reactome: R-HSA-6798695
Reactome: R-HSA-8854214
Reactome: R-HSA-8873719
Reactome: R-HSA-8876198
Reactome: R-HSA-9013148
Reactome: R-HSA-9013149
Reactome: R-HSA-9013404
Reactome: R-HSA-9013405
Reactome: R-HSA-9013406
Reactome: R-HSA-9013407
Reactome: R-HSA-9013408
Reactome: R-HSA-9013409
Reactome: R-HSA-9013423
Reactome: R-HSA-9035034
Reactome: R-HSA-9636383
Reactome: R-HSA-9636569
Cellular Localisation Cytoplasmic Vesicle
Phagosome Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Late Endosome Membrane
Lysosome Membrane
Melanosome Membrane
Autophagosome Membrane
Lipid Droplet
Endosome Membrane
Mitochondrion Membrane
Colocalizes With Osbpl1a At The Late Endosome
Found In The Ruffled Border (A Late Endosomal-Like Compartment In The Plasma Membrane) Of Bone-Resorbing Osteoclasts
Recruited To Phagosomes Containing S
Aureus Or Mycobacterium
Lipid Droplet Localization Is Increased Upon Adrb2 Stimulation
Recruited To Damaged Mitochondria During Mitophagy In A Rimoc1-Dependent Manner
Alternative ELISA Names Ras-Related Protein Rab-7a ELISA kit
RAB7A ELISA kit
RAB7 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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