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  • 产品名称：Human RANTES (Regulated On Activation In Normal T-Cell Expressed And Secreted) Sandwich ELISA Kit Ready-To-Use (STJE0006991)

  • 产品型号：STJE0006991
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human RANTES (Regulated On Activation In Normal T-Cell Expressed And Secreted) Sandwich ELISA Kit Ready-To-Use (STJE0006991)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.073ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This RANTES Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: CCL5
Gene ID: 6352
Uniprot ID: CCL5_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Tissue Specificity Expressed in the follicular fluid (at protein level). T-cell and macrophage specific.
Post Translational Modifications N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from peripheral blood leukocytes and cultured sarcoma cells. N-terminal processed form RANTES(4-68) is produced by proteolytic cleavage by cathepsin CTSG. The identity of the O-linked saccharides at Ser-27 and Ser-28 are not reported in PubMed:1380064. They are assigned by similarity.
Function Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.
Protein Name C-C Motif Chemokine 5
Eocp
Eosinophil Chemotactic Cytokine
Sis-Delta
Small-Inducible Cytokine A5
T Cell-Specific Protein P228
Tcp228
T-Cell-Specific Protein Rantes Cleaved Into - Rantes(3-68 - Rantes(4-68
Database Links Reactome: R-HSA-380108
Reactome: R-HSA-418594
Reactome: R-HSA-6783783
Cellular Localisation Secreted
Alternative ELISA Names C-C Motif Chemokine 5 ELISA kit
Eocp ELISA kit
Eosinophil Chemotactic Cytokine ELISA kit
Sis-Delta ELISA kit
Small-Inducible Cytokine A5 ELISA kit
T Cell-Specific Protein P228 ELISA kit
Tcp228 ELISA kit
T-Cell-Specific Protein Rantes Cleaved Into - Rantes(3-68 - Rantes(4-68 ELISA kit
CCL5 ELISA kit
D17S136E ELISA kit
SCYA5 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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