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  • 产品名称：Human RASSF1 (Ras Association Domain Containing Protein 1) Sandwich ELISA Kit (STJE0011838)

  • 产品型号：STJE0011838
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human RASSF1 (Ras Association Domain Containing Protein 1) Sandwich ELISA Kit (STJE0011838)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.055ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This RASSF1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: RASSF1
Gene ID: 11186
Uniprot ID: RASF1_HUMAN
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Isoform A and isoform C are ubiquitously expressed in all tissues tested, however isoform A is absent in many corresponding cancer cell lines. Isoform B is mainly expressed in hematopoietic cells.
Post Translational Modifications
Function Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.
Protein Name Ras Association Domain-Containing Protein 1
Database Links
Cellular Localisation Isoform A: Cytoplasm
Cytoskeleton
Cytoplasm
Microtubule Organizing Center
Centrosome
Spindle
Spindle Pole
Nucleus
Localizes To Cytoplasmic Microtubules During Interphase
To Bipolar Centrosomes Associated With Microtubules During Prophase
To Spindle Fibers And Spindle Poles At Metaphase And Anaphase
To The Midzone During Early Telophase
And To The Midbody In Late Telophase In Cells
Colocalizes With Mdm2 In The Nucleus
Isoform C: Nucleus
Predominantly Nuclear
Alternative ELISA Names Ras Association Domain-Containing Protein 1 ELISA kit
RASSF1 ELISA kit
RDA32 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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