产品详情
查看大图

  • 产品名称：Anti-CENPS antibody (70-150 aa) (STJ191687)

  • 产品型号：STJ191687
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Anti-CENPS antibody (70-150 aa) (STJ191687)
详情介绍：
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Centromere protein S (70-150 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CENPS
Gene ID: 100526739/378708
Uniprot ID: CENPS_HUMAN
Immunogen Region: 70-150 aa
Specificity: CENPS Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from the human protein at the amino acid range 70-150
Function DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPX (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPX and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks. In complex with CENPT, CENPW and CENPX (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure. DNA-binding function is fulfilled in the presence of CENPX, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own.
Protein Name Centromere Protein S
Cenp-S
Apoptosis-Inducing Taf9-Like Domain-Containing Protein 1
Fancm-Associated Histone Fold Protein 1
Fancm-Interacting Histone Fold Protein 1
Fanconi Anemia-Associated Polypeptide Of 16 Kda
Database Links Reactome: R-HSA-141444
Reactome: R-HSA-2467813
Reactome: R-HSA-2500257
Reactome: R-HSA-5663220
Reactome: R-HSA-606279
Reactome: R-HSA-6783310
Reactome: R-HSA-68877
Reactome: R-HSA-9648025
Cellular Localisation Nucleus
Chromosome
Centromere
Kinetochore
Assembly Of Cenps And Cenpx And Its Partner Subunits Cenpt And Cenpw At Centromeres Occurs Through A Dynamic Exchange Mechanism
Although Exchange Is Continuous In The Cell Cycle
De Novo Assembly Starts Principally During Mid-Late S Phase And Is Complete By G2
Cenps Is More Stably Bound At The Kinetochore Than Cenpx
During S Phase
Rapidly Recruited To Dna Interstrand Cross-Links That Block Replication
Recruited To Dna Damage Sites About 20 Minutes Following Uv Irradiation
Reaching A Plateau After Approximately 40 Minutes
Alternative Antibody Names Anti-Centromere Protein S antibody
Anti-Cenp-S antibody
Anti-Apoptosis-Inducing Taf9-Like Domain-Containing Protein 1 antibody
Anti-Fancm-Associated Histone Fold Protein 1 antibody
Anti-Fancm-Interacting Histone Fold Protein 1 antibody
Anti-Fanconi Anemia-Associated Polypeptide Of 16 Kda antibody
Anti-CENPS antibody
Anti-APITD1 antibody
Anti-FAAP16 antibody
Anti-MHF1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 

沪公网安备 31011002002624号