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  • 产品名称：Anti-CCND2 antibody (1-289) (STJ115249)

  • 产品型号：STJ115249
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CCND2 antibody (1-289) (STJ115249)
详情介绍：
Host: Rabbit
Applications: WB/IHC/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Cyclin D2 (1-289) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:100-1:500
IHC-P 1:50-1:200
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CCND2
Gene ID: 894
Uniprot ID: CCND2_HUMAN
Immunogen Region: 1-289
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-289 of human Cyclin D2 (NP_001750.1).
Immunogen Sequence: MELLCHEVDPVRRAVRDRNL LRDDRVLQNLLTIEERYLPQ CSYFKCVQKDIQPYMRRMVA TWMLEVCEEQKCEEEVFPLA MNYLDRFLAGVPTPKSHLQL LGAVCMFLASKLKETSPLTA EKLCIYTDNSIKPQELLEWE LVVLGKLKWNLAAVTPHDFI EHILRKLPQQREKLSLIRKH AQTFIALCATDFKFAMYPPS MIATGSVGAAICGLQQDEEV SSLTCDALTELLAKITNTD
Post Translational Modifications Phosphorylation at Thr-280 by MAP kinases is required for ubiquitination and degradation by the DCX(AMBRA1) complex. Ubiquitinated by the DCX(AMBRA1) complex during the transition from G1 to S cell phase, leading to its degradation: ubiquitination is dependent on Thr-280 phosphorylation. The DCX(AMBRA1) complex represents the major regulator of CCND2 stability during the G1/S transition. Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.
Function Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals.
Protein Name G1/S-Specific Cyclin-D2
Database Links Reactome: R-HSA-69231
Reactome: R-HSA-8934593
Reactome: R-HSA-9661069
Reactome: R-HSA-9754119
Cellular Localisation Nucleus
Cytoplasm
Nucleus Membrane
Cyclin D-Cdk4 Complexes Accumulate At The Nuclear Membrane And Are Then Translocated Into The Nucleus Through Interaction With Kip/Cip Family Members
Isoform 2: Cytoplasm
Alternative Antibody Names Anti-G1/S-Specific Cyclin-D2 antibody
Anti-CCND2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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