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  • 产品名称：Anti-CCND2 antibody (240-289 aa) (STJ92539)

  • 产品型号：STJ92539
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CCND2 antibody (240-289 aa) (STJ92539)
详情介绍：
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-G1/S-specific cyclin-D2 (240-289 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CCND2
Gene ID: 894
Uniprot ID: CCND2_HUMAN
Immunogen Region: 240-289 aa
Specificity: Cyclin D2 Polyclonal Antibody detects endogenous levels of Cyclin D2 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human CCND2 at the amino acid range 240-289
Function Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals.
Protein Name G1/S-Specific Cyclin-D2
Database Links Reactome: R-HSA-69231
Reactome: R-HSA-8934593
Reactome: R-HSA-9661069
Reactome: R-HSA-9754119
Cellular Localisation Nucleus
Cytoplasm
Nucleus Membrane
Cyclin D-Cdk4 Complexes Accumulate At The Nuclear Membrane And Are Then Translocated Into The Nucleus Through Interaction With Kip/Cip Family Members
Isoform 2: Cytoplasm
Alternative Antibody Names Anti-G1/S-Specific Cyclin-D2 antibody
Anti-CCND2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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