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  • 产品名称：Human LGMN (Legumain) Sandwich ELISA Kit (STJE0010330)

  • 产品型号：STJE0010330
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human LGMN (Legumain) Sandwich ELISA Kit (STJE0010330)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.118ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This LGMN Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: LGMN
Gene ID: 5641
Uniprot ID: LGMN_HUMAN
Sample Type: serum, plasma, tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Ubiquitous. Particularly abundant in kidney, heart and placenta.
Post Translational Modifications Activated by autocatalytic processing at pH 4.
Function Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation.
Protein Name Legumain
Asparaginyl Endopeptidase
Aep
Protease - Cysteine 1
Database Links Reactome: R-HSA-1679131
Reactome: R-HSA-196791
Reactome: R-HSA-2132295
Cellular Localisation Lysosome
Alternative ELISA Names Legumain ELISA kit
Asparaginyl Endopeptidase ELISA kit
Aep ELISA kit
Protease - Cysteine 1 ELISA kit
LGMN ELISA kit
PRSC1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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