产品详情
查看大图

  • 产品名称：Anti-CD155 antibody (Extracellular region) [M048] (STJA0005333)

  • 产品型号：STJA0005333-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Anti-CD155 antibody (Extracellular region) [M048] (STJA0005333)
详情介绍：
Host: Mouse
Applications: WB/IP/ICC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-CD155/PVR (Extracellular region) is suitable for use in Western Blot, Immunoprecipitation and Immunocytochemistry research applications.
Clonality: Monoclonal
Clone ID: M048
Conjugation: Unconjugated
Isotype: IgG1
Formulation: PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Purification: Protein G Purified
Dilution Range: WB 1:1000
IHC
ICC 1:100
IP 1:100
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PVR
Gene ID: 5817
Uniprot ID: PVR_HUMAN
Immunogen Region: Extracellular region
Specificity: Clone M048 mouse monoclonal antibody detects a 75 kDa* protein on SDS-PAGE Native" or denatured immunoblots of human A549, NCI-H466, NCI-H1299, MDA-MB-231 and A431 carcinomas. The antibody detects CD155 in the membranes and cytoplasm in NCI-H446 cell
Immunogen: Clone (M048) was generated from a recombinant protein that included the extracellular region of human CD155 protein.
Post Translational Modifications N-glycosylated. N-glycan at Asn-120: Hex5HexNAc4. Phosphorylated by Src kinases on tyrosine residues in the ITIM motif upon ligation. Interaction with TIGIT is required for Phosphorylation.
Function Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytotoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. (Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport. (Microbial infection) Acts as a receptor for Pseudorabies virus. (Microbial infection) Is prevented to reach cell surface upon infection by Human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells.
Protein Name Poliovirus Receptor
Nectin-Like Protein 5
Necl-5
Cd Antigen Cd155
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-420597
Cellular Localisation Isoform Alpha: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform Delta: Cell Membrane
Isoform Beta: Secreted
Isoform Gamma: Secreted
Alternative Antibody Names Anti-Poliovirus Receptor antibody
Anti-Nectin-Like Protein 5 antibody
Anti-Necl-5 antibody
Anti-Cd Antigen Cd155 antibody
Anti-PVR antibody
Anti-PVS antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 

沪公网安备 31011002002624号