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  • 产品名称：Anti-BMP2 antibody (288-300) (STJ73753)

  • 产品型号：STJ73753-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-BMP2 antibody (288-300) (STJ73753)
详情介绍：
Host: Goat
Applications: Pep-ELISA/IF
Reactivity: Human/Mouse/Rat/Dog/Pig/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-BMP2 (288-300) is suitable for use in ELISA and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: IF-Strong expression of the protein seen in the vesicles of HEK293 cells. 10µg/ml
ELISA-antibody detection limit dilution 1:128000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: BMP2
Gene ID: 650
Uniprot ID: BMP2_HUMAN
Immunogen Region: 288-300
Accession Number: NP_001191.1
Specificity: This antibody is expected to recognize N terminus of mature protein.
Immunogen Sequence: QRKRLKSSCKRHP
Function Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Induces cartilage and bone formation. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Also acts to promote expression of HAMP, via the interaction with its receptor BMPR1A/ALK3. Can also signal through non-canonical pathways such as ERK/MAP kinase signaling cascade that regulates osteoblast differentiation. Also stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway by stimulating EIF2A phosphorylation which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling.
Protein Name Bone Morphogenetic Protein 2
Bmp-2
Bone Morphogenetic Protein 2a
Bmp-2a
Database Links Reactome: R-HSA-201451
Reactome: R-HSA-2129379
Reactome: R-HSA-8878166
Reactome: R-HSA-8939902
Cellular Localisation Secreted
Alternative Antibody Names Anti-Bone Morphogenetic Protein 2 antibody
Anti-Bmp-2 antibody
Anti-Bone Morphogenetic Protein 2a antibody
Anti-Bmp-2a antibody
Anti-BMP2 antibody
Anti-BMP2A antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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