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  • 产品名称：Human NISCH (Nischarin) Sandwich ELISA Kit Ready-To-Use (STJE0017362)

  • 产品型号：STJE0017362
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human NISCH (Nischarin) Sandwich ELISA Kit Ready-To-Use (STJE0017362)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.067ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This NISCH Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: NISCH
Gene ID: 11188
Uniprot ID: NISCH_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Isoform 1, isoform 3 and isoform 4 are expressed in brain. Isoform 1 is expressed in endocrine tissues.
Post Translational Modifications
Function Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension. Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons. Acts as a modulator of Rac-regulated signal transduction pathways. Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity. Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation. Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation. Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells. Inhibits lamellipodia formation, when overexpressed. Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures.
Protein Name Nischarin
Imidazoline Receptor 1
I-1
Ir1
Imidazoline Receptor Antisera-Selected Protein
Hiras
Imidazoline-1 Receptor
I1r
Imidazoline-1 Receptor Candidate Protein
I-1 Receptor Candidate Protein
I1r Candidate Protein
Database Links Reactome: R-HSA-9013149
Reactome: R-HSA-9696264
Reactome: R-HSA-9696270
Cellular Localisation Cell Membrane
Cytoplasm
Early Endosome
Recycling Endosome
Enriched In The Early/Sorting And Recycling Endosomes
Colocalized In Early/Sorting Endosomes With Eea1 And Snx2 And In Recycling Endosomes With Transferrin Receptor
Detected In The Perinuclear Region Partially Associated With Punctate Structures
Colocalizes With Pak1 In Cytoplasm
Vesicular Structures In The Perinuclear Area And Membrane Ruffles
Colocalizes With Rac1 In The Cytoplasm And Vesicles Structures
Colocalized With Mapk1 And Mapk3 In Rvlm Neurons
Alternative ELISA Names Nischarin ELISA kit
Imidazoline Receptor 1 ELISA kit
I-1 ELISA kit
Ir1 ELISA kit
Imidazoline Receptor Antisera-Selected Protein ELISA kit
Hiras ELISA kit
Imidazoline-1 Receptor ELISA kit
I1r ELISA kit
Imidazoline-1 Receptor Candidate Protein ELISA kit
I-1 Receptor Candidate Protein ELISA kit
I1r Candidate Protein ELISA kit
NISCH ELISA kit
IRAS ELISA kit
KIAA0975 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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