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  • 产品名称：Human PDCD6IP (Programmed Cell Death Protein 6 Interacting Protein) Sandwich ELISA Kit (STJE0011330)

  • 产品型号：STJE0011330
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human PDCD6IP (Programmed Cell Death Protein 6 Interacting Protein) Sandwich ELISA Kit (STJE0011330)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.107ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This PDCD6IP Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: PDCD6IP
Gene ID: 10015
Uniprot ID: PDC6I_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity
Post Translational Modifications May be phosphorylated on tyrosine residues by activated PDGFRB.
Function Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP. By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier. (Microbial infection) Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release.this function requires the interaction with CHMP4B. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as enveloped virus budding (HIV-1 and other lentiviruses).
Protein Name Programmed Cell Death 6-Interacting Protein
Pdcd6-Interacting Protein
Alg-2-Interacting Protein 1
Alg-2-Interacting Protein X
Hp95
Database Links Reactome: R-HSA-162588
Reactome: R-HSA-5210891
Reactome: R-HSA-5213460
Reactome: R-HSA-5675482
Cellular Localisation Cytoplasm
Cytosol
Melanosome
Cytoskeleton
Microtubule Organizing Center
Centrosome
Secreted
Extracellular Exosome
Cell Junction
Tight Junction
Midbody
Midbody Ring
Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv
Colocalized With Cep55 At Centrosomes Of Non-Dividing Cells
Component Of The Actomyosin-Tight Junction Complex
Pdcd6ip Targeting To The Midbody Requires The Interaction With Cep55
Alternative ELISA Names Programmed Cell Death 6-Interacting Protein ELISA kit
Pdcd6-Interacting Protein ELISA kit
Alg-2-Interacting Protein 1 ELISA kit
Alg-2-Interacting Protein X ELISA kit
Hp95 ELISA kit
PDCD6IP ELISA kit
AIP1 ELISA kit
ALIX ELISA kit
KIAA1375 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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