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  • 产品名称：Anti-CD74 antibody (73-232) (STJ27634)

  • 产品型号：STJ27634
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CD74 antibody (73-232) (STJ27634)
详情介绍：
Host: Rabbit
Applications: WB/IHC/IF
Reactivity: Human/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CD74 (73-232) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:100-1:500
IHC-P 1:50-1:200
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CD74
Gene ID: 972
Uniprot ID: HG2A_HUMAN
Immunogen Region: 73-232
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 73-232 of human CD74 (NP_004346.1).
Immunogen Sequence: QQQGRLDKLTVTSQNLQLEN LRMKLPKPPKPVSKMRMATP LLMQALPMGALPQGPMQNAT KYGNMTEDHVMHLLQNADPL KVYPPLKGSFPENLRHLKNT METIDWKVFESWMHHWLLFE MSRHSLEQKPTDAPPKESLE LEDPSSGLGVTKQDLGPVPM
Tissue Specificity Detected in urine (at protein level). Isoform p41: In B cells, represents 10% of total CD74 expression. Isoform p33: In B cells, represents 70% of total CD74 expression.
Post Translational Modifications O-glycosylated with core 1 or possibly core 8 glycans. Contains chondroitin sulfate.
Function Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. Class-II-associated invariant chain peptide: Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome. Isoform p41: Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2. Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform.
Protein Name Hla Class Ii Histocompatibility Antigen Gamma Chain
Hla-Dr Antigens-Associated Invariant Chain
Ia Antigen-Associated Invariant Chain
Ii
Cd Antigen Cd74 Cleaved Into - Class-Ii-Associated Invariant Chain Peptide
Clip
Database Links Reactome: R-HSA-202733
Reactome: R-HSA-2132295
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Endoplasmic Reticulum Membrane
Golgi Apparatus
Trans-Golgi Network
Endosome
Lysosome
Secreted
Transits Through A Number Of Intracellular Compartments In The Endocytic Pathway
It Can Either Undergo Proteolysis Or Reach The Cell Membrane
Isoform P41: Late Endosome
Alternative Antibody Names Anti-Hla Class Ii Histocompatibility Antigen Gamma Chain antibody
Anti-Hla-Dr Antigens-Associated Invariant Chain antibody
Anti-Ia Antigen-Associated Invariant Chain antibody
Anti-Ii antibody
Anti-Cd Antigen Cd74 Cleaved Into - Class-Ii-Associated Invariant Chain Peptide antibody
Anti-Clip antibody
Anti-CD74 antibody
Anti-DHLAG antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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