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  • 产品名称：Anti-CEP63 antibody (1-300) (STJ117711)

  • 产品型号：STJ117711
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CEP63 antibody (1-300) (STJ117711)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CEP63 (1-300) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:200-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CEP63
Gene ID: 80254
Uniprot ID: CEP63_HUMAN
Immunogen Region: 1-300
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CEP63 (NP_001035859.1).
Immunogen Sequence: MEALLEGIQNRGHGGGFLTS CEAELQELMKQIDIMVAHKK SEWEGRTHALETCLKIREQE LKSLRSQLDVTHKEVGMLHQ QVEEHEKIKQEMTMEYKQEL KKLHEELCILKRSYEKLQKK QMREFRGNTKNHREDRSEIE RLTAKIEEFRQKSLDWEKQR LIYQQQVSSLEAQRKALAEQ SEIIQAQLVNRKQKLESVEL SSQSEIQHLSSKLERANDTI CANELEIERLTMRVNDLVG
Post Translational Modifications Polyubiquitinated via 'Lys-48'-linked ubiquitin, leading to its degradation. Deubiquitinated by USP36, promoting its stabilization.
Function Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication.the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152.however, this function has been questioned. Also recruits CDK1 to centrosomes. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes.this leads to the inactivation of spindle assembly and delay in mitotic progression. Promotes stabilization of FXR1 protein by inhibiting FXR1 ubiquitination.
Protein Name Centrosomal Protein Of 63 Kda
Cep63
Database Links Reactome: R-HSA-2565942
Reactome: R-HSA-380259
Reactome: R-HSA-380270
Reactome: R-HSA-380284
Reactome: R-HSA-380320
Reactome: R-HSA-5620912
Reactome: R-HSA-8854518
Cellular Localisation Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Centriole
Centriolar Satellite
Colocalizes With Cdk5rap2
Cep152 And Wdr62 In A Discrete Ring Around The Proximal End Of The Parental Centriole
At This Site
A Cohesive Structure Is Predicted To Engage Parental Centrioles And Procentrioles
Alternative Antibody Names Anti-Centrosomal Protein Of 63 Kda antibody
Anti-Cep63 antibody
Anti-CEP63 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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