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  • 产品名称：Anti-CAPRIN1 antibody (Internal) (STJ73106)

  • 产品型号：STJ73106-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CAPRIN1 antibody (Internal) (STJ73106)
详情介绍：
Host: Goat
Applications: Pep-ELISA/WB/IHC
Reactivity: Human/Rat/Dog/Pig
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-CAPRIN1 (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: IHC-5µg/ml
ELISA-antibody detection limit dilution 1:16000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: CAPRIN1
Gene ID: 4076
Uniprot ID: CAPR1_HUMAN
Immunogen Region: Internal
Accession Number: NP_005889.3; NP_976240.1
Specificity: This antibody is expected to recognize both reported isoforms (NP_005889.3; NP_976240.1).
Immunogen Sequence: EQRPQKEPIDQ
Post Translational Modifications Tyrosine phosphorylation by EPHA4 promotes interaction with FMR1 and liquid-liquid phase separation (LLPS) for the formation of a membraneless compartment that concentrates mRNAs with associated regulatory factors. O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. O-glycosylation by OGT inhibit ability to undergo liquid-liquid phase separation (LLPS).
Function mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors. Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs. In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation. Binds directly and selectively to MYC and CCND2 mRNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs.
Protein Name Caprin-1
Cell Cycle-Associated Protein 1
Cytoplasmic Activation- And Proliferation-Associated Protein 1
Gpi-Anchored Membrane Protein 1
Gpi-Anchored Protein P137
Gpi-P137
P137gpi
Membrane Component Chromosome 11 Surface Marker 1
Rna Granule Protein 105
Cellular Localisation Cytoplasm
Cytoplasmic Ribonucleoprotein Granule
Cytosol
Cell Projection
Dendrite
Lamellipodium
Mediates Formation And Localizes To Cytoplasmic Ribonucleoprotein Membraneless Compartments
Associated With Rna Granules
At The Leading Edge Of Migrating Fibroblasts
Colocalizes With Ddx3x
Alternative Antibody Names Anti-Caprin-1 antibody
Anti-Cell Cycle-Associated Protein 1 antibody
Anti-Cytoplasmic Activation- And Proliferation-Associated Protein 1 antibody
Anti-Gpi-Anchored Membrane Protein 1 antibody
Anti-Gpi-Anchored Protein P137 antibody
Anti-Gpi-P137 antibody
Anti-P137gpi antibody
Anti-Membrane Component Chromosome 11 Surface Marker 1 antibody
Anti-Rna Granule Protein 105 antibody
Anti-CAPRIN1 antibody
Anti-GPIAP1 antibody
Anti-GPIP137 antibody
Anti-M11S1 antibody
Anti-RNG105 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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