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  • 产品名称：Anti-CFH antibody (STJA0007949)

  • 产品型号：STJA0007949
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CFH antibody (STJA0007949)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Complement factor H is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CFH
Gene ID: 3075
Uniprot ID: CFAH_HUMAN
Specificity: This antibody detects endogenous levels of Complement factor H at Human, Mouse
Immunogen: Synthesized peptide derived from human Complement factor H
Post Translational Modifications Sulfated on tyrosine residues.
Function Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed. (Microbial infection) In the mosquito midgut, binds to the surface of parasite P.falciparum gametocytes and protects the parasite from alternative complement pathway-mediated elimination.
Protein Name Complement Factor H
H Factor 1
Database Links Reactome: R-HSA-977606
Cellular Localisation Secreted
(Microbial Infection) In The Mosquito Midgut
Localizes To P
Falciparum (Nf54 Strain) Macrogamete And Young Zygote Cell Membranes
Alternative Antibody Names Anti-Complement Factor H antibody
Anti-H Factor 1 antibody
Anti-CFH antibody
Anti-HF antibody
Anti-HF1 antibody
Anti-HF2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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