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  • 产品名称：Human SETD7 (SET Domain Containing Protein 7) Sandwich ELISA Kit Ready-To-Use (STJE0018502)

  • 产品型号：STJE0018502
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human SETD7 (SET Domain Containing Protein 7) Sandwich ELISA Kit Ready-To-Use (STJE0018502)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.054ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This SETD7 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: SETD7
Gene ID: 80854
Uniprot ID: SETD7_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Widely expressed. Expressed in pancreatic islets.
Post Translational Modifications
Function Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the KR-STA-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Monomethylates 'Lys-491' of CGAS, promoting interaction between SGF29 and CGAS.
Protein Name Histone-Lysine N-Methyltransferase Setd7
Histone H3-K4 Methyltransferase Setd7
H3-K4-Hmtase Setd7
Lysine N-Methyltransferase 7
Set Domain-Containing Protein 7
Set7/9
Database Links Reactome: R-HSA-3214841
Cellular Localisation Nucleus
Chromosome
Alternative ELISA Names Histone-Lysine N-Methyltransferase Setd7 ELISA kit
Histone H3-K4 Methyltransferase Setd7 ELISA kit
H3-K4-Hmtase Setd7 ELISA kit
Lysine N-Methyltransferase 7 ELISA kit
Set Domain-Containing Protein 7 ELISA kit
Set7/9 ELISA kit
SETD7 ELISA kit
KIAA1717 ELISA kit
KMT7 ELISA kit
SET7 ELISA kit
SET9 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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