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  • 产品名称：Human SIRT3 (Sirtuin 3) Sandwich ELISA Kit (STJE0012174)

  • 产品型号：STJE0012174
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human SIRT3 (Sirtuin 3) Sandwich ELISA Kit (STJE0012174)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.124ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This SIRT3 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: SIRT3
Gene ID: 23410
Uniprot ID: SIR3_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Widely expressed.
Post Translational Modifications Processed by mitochondrial processing peptidase (MPP) to give a 28 kDa product. Such processing is probably essential for its enzymatic activity.
Function NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5PO. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels. In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription. Acts as a regulator of ceramide metabolism by mediating deacetylation of ceramide synthases CERS1, CERS2 and CERS6, thereby increasing their activity and promoting mitochondrial ceramide accumulation. Regulates hepatic lipogenesis. Uses NAD(+) substrate imported by SLC25A47, triggering downstream activation of PRKAA1/AMPK-alpha signaling cascade that ultimately downregulates sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance.
Protein Name Nad-Dependent Protein Deacetylase Sirtuin-3 - Mitochondrial
Hsirt3
Regulatory Protein Sir2 Homolog 3
Sir2-Like Protein 3
Database Links Reactome: R-HSA-2151201
Reactome: R-HSA-9615017
Reactome: R-HSA-9617629
Cellular Localisation Mitochondrion Matrix
Alternative ELISA Names Nad-Dependent Protein Deacetylase Sirtuin-3 - Mitochondrial ELISA kit
Hsirt3 ELISA kit
Regulatory Protein Sir2 Homolog 3 ELISA kit
Sir2-Like Protein 3 ELISA kit
SIRT3 ELISA kit
SIR2L3 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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