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  • 产品名称：Anti-CHL1 antibody (140-220 aa) (STJ191053)

  • 产品型号：STJ191053
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CHL1 antibody (140-220 aa) (STJ191053)
详情介绍：
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Neural cell adhesion molecule L1-like protein (140-220 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CHL1
Gene ID: 10752
Uniprot ID: NCHL1_HUMAN
Immunogen Region: 140-220 aa
Specificity: CHL1 Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from the human protein at the amino acid range 140-220
Post Translational Modifications Cleavage by metalloprotease ADAM8 in the extracellular part generates 2 soluble forms (125 kDa and 165 kDa) in vitro and is inhibited by metalloprotease inhibitors. Cleaved by BACE1. N-glycosylated. Contains N-linked oligosaccharides with a sulfated carbohydrate structure type HNK-1 (SO4-3-GlcUABeta1,3GalBeta1,4GlcNAc). O-glycosylated.
Function Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane.
Protein Name Neural Cell Adhesion Molecule L1-Like Protein
Close Homolog Of L1 Cleaved Into - Processed Neural Cell Adhesion Molecule L1-Like Protein
Database Links Reactome: R-HSA-447041
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Soluble Forms Produced By Cleavage/Shedding Also Exist
Processed Neural Cell Adhesion Molecule L1-Like Protein: Secreted
Extracellular Space
Extracellular Matrix
Alternative Antibody Names Anti-Neural Cell Adhesion Molecule L1-Like Protein antibody
Anti-Close Homolog Of L1 Cleaved Into - Processed Neural Cell Adhesion Molecule L1-Like Protein antibody
Anti-CHL1 antibody
Anti-CALL antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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