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  • 产品名称：Human SLC30A1 (Solute Carrier Family 30, Member 1) Sandwich ELISA Kit (STJE0012192)

  • 产品型号：STJE0012192
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human SLC30A1 (Solute Carrier Family 30, Member 1) Sandwich ELISA Kit (STJE0012192)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.057ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This SLC30A1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: SLC30A1
Gene ID: 7779
Uniprot ID: ZNT1_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity
Post Translational Modifications N-glycosylated at Asn-299. N-glycosylation promotes endocytosis and degradation through the proteasomal or lysosomal pathways.
Function Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity. Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells. In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them.
Protein Name Proton-Coupled Zinc Antiporter Slc30a1
Solute Carrier Family 30 Member 1
Zinc Transporter 1
Database Links Reactome: R-HSA-435368
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Basolateral Cell Membrane
Cytoplasmic Vesicle Membrane
Localization To The Plasma Membrane Is Regulated By Cellular Zinc Status
Recruitment To The Plasma Membrane From An Internal Pool Is Stimulated By Zinc While In Absence Of Zinc The Plasma Membrane Pool Is Endocytosed And Degraded
Localizes To The Basolateral Surface Of Enterocytes
Localizes To Zinc-Containing Intracellular Vesicles In Macrophages
Alternative ELISA Names Proton-Coupled Zinc Antiporter Slc30a1 ELISA kit
Solute Carrier Family 30 Member 1 ELISA kit
Zinc Transporter 1 ELISA kit
SLC30A1 ELISA kit
ZNT1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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