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  • 产品名称：Human SLC39A6 (Solute Carrier Family 39, Member 6) Sandwich ELISA Kit (STJE0012211)

  • 产品型号：STJE0012211
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human SLC39A6 (Solute Carrier Family 39, Member 6) Sandwich ELISA Kit (STJE0012211)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.114ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This SLC39A6 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: SLC39A6
Gene ID: 25800
Uniprot ID: S39A6_HUMAN
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Highly expressed in the breast, prostate, placenta, kidney, pituitary and corpus callosum. Weakly expressed in heart and intestine. Also highly expressed in cells derived from an adenocarcinoma of the cervix and lung carcinoma.
Post Translational Modifications Cleaved on the N-terminus before locating to the plasma membrane. N-glycosylated. Phosphorylated by ZAP70 in response to TCR stimulation leading to its activation.
Function Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT. Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as CDH1, causing loss of cell adherence. In addition, the SLC39A10-SLC39A6 heterodimer plays an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis. Participates in the T-cell receptor signaling regulation by mediating cellular zinc uptake into activated lymphocytes. Regulates the zinc influx necessary for proper meiotic progression to metaphase II (MII) that allows the oocyte-to-egg transition.
Protein Name Zinc Transporter Zip6
Estrogen-Regulated Protein Liv-1
Solute Carrier Family 39 Member 6
Zrt- And Irt-Like Protein 6
Zip-6
Database Links Reactome: R-HSA-442380
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Cell Projection
Lamellipodium Membrane
Membrane Raft
Apical Cell Membrane
Localizes To Lipid Rafts In T Cells And Is Recruited Into The Immunological Synapse In Response To Tcr Stimulation
In The Choroid Plexus Is Limited To The Apical Membrane In Epithelial Cells
Alternative ELISA Names Zinc Transporter Zip6 ELISA kit
Estrogen-Regulated Protein Liv-1 ELISA kit
Solute Carrier Family 39 Member 6 ELISA kit
Zrt- And Irt-Like Protein 6 ELISA kit
Zip-6 ELISA kit
SLC39A6 ELISA kit
LIV1 ELISA kit
ZIP6 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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