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  • 产品名称：Anti-CBARA1 antibody (113-126) (STJ72551)

  • 产品型号：STJ72551-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CBARA1 antibody (113-126) (STJ72551)
详情介绍：
Host: Goat
Applications: Pep-ELISA/WB/IHC
Reactivity: Human/Mouse/Rat/Dog/Pig/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-CBARA1 (113-126) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-0.5-2µg/ml
IHC-3.75µg/ml
ELISA-antibody detection limit dilution 1:32000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: MICU1
Gene ID: 10367
Uniprot ID: MICU1_HUMAN
Immunogen Region: 113-126
Accession Number: NP_006068.2; NP_001182447.1
Specificity: This antibody is expected to recognize reported isoforms 1 and 2 (NP_006068.2; NP_001182447.1).
Immunogen Sequence: EYENRIRAYSTPDK
Function Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening. Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG.
Protein Name Calcium Uptake Protein 1 - Mitochondrial
Atopy-Related Autoantigen Calc
Ara Calc
Calcium-Binding Atopy-Related Autoantigen 1
Allergen Hom S 4
Database Links Reactome: R-HSA-8949215
Reactome: R-HSA-8949664
Cellular Localisation Mitochondrion Inner Membrane
Single-Pass Membrane Protein
Mitochondrion Intermembrane Space
Alternative Antibody Names Anti-Calcium Uptake Protein 1 - Mitochondrial antibody
Anti-Atopy-Related Autoantigen Calc antibody
Anti-Ara Calc antibody
Anti-Calcium-Binding Atopy-Related Autoantigen 1 antibody
Anti-Allergen Hom S 4 antibody
Anti-MICU1 antibody
Anti-CALC antibody
Anti-CBARA1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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