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  • 产品名称：Human SNAP25 (Synaptosomal Associated Protein 25kDa) Sandwich ELISA Kit Ready-To-Use (STJE0018632)

  • 产品型号：STJE0018632
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human SNAP25 (Synaptosomal Associated Protein 25kDa) Sandwich ELISA Kit Ready-To-Use (STJE0018632)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.059ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This SNAP25 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: SNAP25
Gene ID: 6616
Uniprot ID: SNP25_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Neurons of the neocortex, hippocampus, piriform cortex, anterior thalamic nuclei, pontine nuclei, and granule cells of the cerebellum.
Post Translational Modifications Palmitoylated. Cys-85 appears to be the main site, and palmitoylation is required for membrane association. (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type A (BoNT/A, botA) which hydrolyzes the 197-Gln-|-Arg-198 bond and inhibits neurotransmitter release. (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type C (BoNT/C) which hydrolyzes the 198-Arg-|-Ala-199 bond and inhibits neurotransmitter release. C.botulinum type C only rarely infects humans. (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type E (BoNT/E) which hydrolyzes the 180-Arg-|-Ile-181 bond and inhibits neurotransmitter release.
Function t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells.
Protein Name Synaptosomal-Associated Protein 25
Snap-25
Super Protein
Sup
Synaptosomal-Associated 25 Kda Protein
Database Links Reactome: R-HSA-181429
Reactome: R-HSA-181430
Reactome: R-HSA-210500
Reactome: R-HSA-212676
Reactome: R-HSA-264642
Reactome: R-HSA-422356
Reactome: R-HSA-449836
Reactome: R-HSA-5250968
Reactome: R-HSA-5250971
Reactome: R-HSA-5250992
Reactome: R-HSA-6798695
Reactome: R-HSA-888590
Reactome: R-HSA-9662360
Cellular Localisation Cytoplasm
Perinuclear Region
Cell Membrane
Lipid-Anchor
Synapse
Synaptosome
Photoreceptor Inner Segment
Membrane Association Requires Palmitoylation
Expressed Throughout Cytoplasm
Concentrating At The Perinuclear Region
Colocalizes With Kcnb1 At The Cell Membrane
Colocalizes With Plcl1 At The Cell Membrane
Alternative ELISA Names Synaptosomal-Associated Protein 25 ELISA kit
Snap-25 ELISA kit
Super Protein ELISA kit
Sup ELISA kit
Synaptosomal-Associated 25 Kda Protein ELISA kit
SNAP25 ELISA kit
SNAP ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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