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  • 产品名称：Anti-CHUK antibody (600-700) (STJ116403)

  • 产品型号：STJ116403
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CHUK antibody (600-700) (STJ116403)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-IKK Alpha (600-700) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CHUK
Gene ID: 1147
Uniprot ID: IKKA_HUMAN
Immunogen Region: 600-700
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 600-700 of human IKK Alpha (NP_001269.3).
Immunogen Sequence: VLKELFGHLSKLLGCKQKII DLLPKVEVALSNIKEADNTV MFMQGKRQKEIWHLLKIACT QSSARSLVGSSLEGAVTPQT SAWLPPTSAEHDHSLSCVVT P
Tissue Specificity Widely expressed.
Post Translational Modifications Phosphorylated by MAP3K14/NIK, AKT and to a lesser extent by MEKK1, and dephosphorylated by PP2A. Autophosphorylated. Ubiquitinated by TRIM56 via 'Lys-63'-linked ubiquitination, promoting activation of CHUK/IKKA. (Microbial infection) Acetylation of Thr-179 by Yersinia YopJ prevents phosphorylation and activation, thus blocking the I-kappa-B signaling pathway.
Function Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Participates also in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities. Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP. Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor. Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death. Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity.
Protein Name Inhibitor Of Nuclear Factor Kappa-B Kinase Subunit Alpha
I-Kappa-B Kinase Alpha
Ikk-A
Ikk-Alpha
Ikbka
Ikappab Kinase
Conserved Helix-Loop-Helix Ubiquitous Kinase
I-Kappa-B Kinase 1
Ikk-1
Ikk1
Nuclear Factor Nf-Kappa-B Inhibitor Kinase Alpha
Nfkbika
Transcription Factor 16
Tcf-16
Database Links Reactome: R-HSA-1169091
Reactome: R-HSA-1236974
Reactome: R-HSA-168638
Reactome: R-HSA-168927
Reactome: R-HSA-1810476
Reactome: R-HSA-198323
Reactome: R-HSA-202424
Reactome: R-HSA-2871837
Reactome: R-HSA-445989
Reactome: R-HSA-5357905
Reactome: R-HSA-5357956
Reactome: R-HSA-5602636
Reactome: R-HSA-5603027
Reactome: R-HSA-5603029
Reactome: R-HSA-5607761
Reactome: R-HSA-5607764
Reactome: R-HSA-5674400
Reactome: R-HSA-5676590
Reactome: R-HSA-5684264
Reactome: R-HSA-9020702
Reactome: R-HSA-933542
Reactome: R-HSA-933543
Reactome: R-HSA-937039
Reactome: R-HSA-937041
Reactome: R-HSA-9705671
Reactome: R-HSA-975144
Reactome: R-HSA-9758274
Cellular Localisation Cytoplasm
Nucleus
Shuttles Between The Cytoplasm And The Nucleus
Alternative Antibody Names Anti-Inhibitor Of Nuclear Factor Kappa-B Kinase Subunit Alpha antibody
Anti-I-Kappa-B Kinase Alpha antibody
Anti-Ikk-A antibody
Anti-Ikk-Alpha antibody
Anti-Ikbka antibody
Anti-Ikappab Kinase antibody
Anti-Conserved Helix-Loop-Helix Ubiquitous Kinase antibody
Anti-I-Kappa-B Kinase 1 antibody
Anti-Ikk-1 antibody
Anti-Ikk1 antibody
Anti-Nuclear Factor Nf-Kappa-B Inhibitor Kinase Alpha antibody
Anti-Nfkbika antibody
Anti-Transcription Factor 16 antibody
Anti-Tcf-16 antibody
Anti-CHUK antibody
Anti-IKKA antibody
Anti-TCF16 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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