产品详情
简单介绍:
Anti-CIAPIN1 antibody (1-312) (STJ28258)
详情介绍:
Host: | Rabbit |
Applications: | WB/IF/IP |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-CIAPIN1 (1-312) is suitable for use in Western Blot, Immunofluorescence and Immunoprecipitation research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000 IF/ICC 1:50-1:200 IP 1:50-1:100 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | CIAPIN1 |
Gene ID: | 57019 |
Uniprot ID: | CPIN1_HUMAN |
Immunogen Region: | 1-312 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-312 of human CIAPIN1 (NP_064709.2). |
Immunogen Sequence: | MADFGISAGQFVAVVWDKSS PVEALKGLVDKLQALTGNEG RVSVENIKQLLQSAHKESSF DIILSGLVPGSTTLHSAEIL AEIARILRPGGCLFLKEPVE TAVDNNSKVKTASKLCSALT LSGLVEVKELQREPLTPEEV QSVREHLGHESDNLLFVQIT GKKPNFEVGSSRQLKLSITK KSSPSVKPAVDPAAAKLWTL SANDMEDDSMDLIDSDELLD PEDLKKPDPASLRAASCGE |
Tissue Specificity | Ubiquitously expressed. Highly expressed in heart, liver and pancreas. |
Function | Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a 4Fe-4S cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells. |
Protein Name | Anamorsin Cytokine-Induced Apoptosis Inhibitor 1 Fe-S Cluster Assembly Protein Dre2 Homolog |
Database Links | Reactome: R-HSA-2564830 |
Cellular Localisation | Cytoplasm Nucleus Mitochondrion Intermembrane Space |
Alternative Antibody Names | Anti-Anamorsin antibody Anti-Cytokine-Induced Apoptosis Inhibitor 1 antibody Anti-Fe-S Cluster Assembly Protein Dre2 Homolog antibody Anti-CIAPIN1 antibody Anti-CUA001 antibody Anti-PRO0915 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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